MAST-EASE™ was formulated to support the body’s natural ability to normalize mast cell and histamine response and to aid in reducing inflammation.* Research shows that Calendula may be supportive for those with histamine-related issues and may reduce inflammation.* Studies reveal that Reishi may modulate the immune system and may inhibit inappropriate histamine response.* Research reveals that Japanese Sophora flowers contain quercetin and may support those with histamine imbalances.* Studies indicate that Grape Seed contains constituents that may inhibit inflammation and may modulate histamine response.* Studies show that Agaricus blazei may contain immunomodulatory benefits, may reduce inflammation, and may inhibit an inappropriate histamine response.*.